Using thousands of sprites and sprites animations with no problems.
What exactly do you mean? Every single pixel of the sprite or its borders?
If borders make sure when you run your game the game window is fully stretched out and not minimized due to Unity's small window.
Sometimes it happens with 2d sprite animations try to slightly change its scale, but this issue happens very, very rare. (possibly something is wrong with the sprite sheets)
Comments
What exactly do you mean? Every single pixel of the sprite or its borders?
If borders make sure when you run your game the game window is fully stretched out and not minimized due to Unity's small window.
Sometimes it happens with 2d sprite animations try to slightly change its scale, but this issue happens very, very rare. (possibly something is wrong with the sprite sheets)